V-DAILY
Serving Size: 1 Packet, Servings Per Container: 30; Vitamin A, Vitamin C, Vitamin D, Vitamin E, Vitamin K, Thiamin (B1), Riboflavin (B2), Niacin, Vitamin B6, Folate, Vitamin B12, Biotin, Pantothenic Acid, Calcium, Iron, Magnesium, Zinc, Iodine, Copper, Chromium, Potassium, Proprietary Fruits/Greens/Mushrooms Blend, Amino Acid Complex Blend, Trace Minerals, Inositol, MSM, Prebiotic + Probiotic Blend, Amla Bioflavonoids, Beet Root Extract, Coenzyme Q10, Boron; Other Ingredients: Not specified
📋 Overview
V-DAILY combines four well-researched micronutrients -— Vitamin A (800mcg), Vitamin C (80mg), a full B-Complex, and Zinc (10mg) -— to support immune defence, energy metabolism, skin integrity, and antioxidant protection. The formulation targets adults with dietary gaps or elevated micronutrient demands, including those under physiological stress, frequent illness, or poor dietary variety. Evidence across individual ingredients is strong (Grade A-B), making this a scientifically grounded daily foundation supplement.
Key Ingredients
- Serving Size: 1 Packet, Servings Per Container: 30
- Vitamin A, Vitamin C, Vitamin D, Vitamin E, Vitamin K, Thiamin (B1), Riboflavin (B2), Niacin, Vitamin B6, Folate, Vitamin B12, Biotin, Pantothenic Acid, Calcium, Iron, Magnesium, Zinc, Iodine, Copper, Chromium, Potassium, Proprietary Fruits/Greens/Mushrooms Blend, Amino Acid Complex Blend, Trace Minerals, Inositol, MSM, Prebiotic + Probiotic Blend, Amla Bioflavonoids, Beet Root Extract, Coenzyme Q10, Boron
- Other Ingredients: Not specified
What Does The Research Say?
Vitamin A at 800mcg (the EU Nutrient Reference Value) plays a central role in maintaining epithelial barrier function and regulating innate and adaptive immunity. A landmark systematic review published in 2010 by Imdad et al. demonstrated that Vitamin A supplementation in deficient populations reduced all-cause childhood mortality by 24% and diarrhoea-related mortality by 28%, underscoring its immune-critical role ((PMID: 21328304)). Mechanistically, retinoic acid -— the active metabolite of Vitamin A -— binds RAR/RXR nuclear receptors to regulate gene transcription involved in T-cell differentiation and mucosal IgA production. Studies have consistently shown that even subclinical Vitamin A insufficiency impairs natural killer cell activity and reduces secretory IgA at mucosal surfaces, the body's first line of immune defence.
Vitamin C at 80mg exerts broad antioxidant and immunomodulatory effects. A pivotal Cochrane meta-analysis by Hemilä and Chalker (2013, (PMID: 23440782)) analysed 29 placebo-controlled trials involving over 11,000 participants and found that regular Vitamin C supplementation reduced common cold duration by 8% in adults and 14% in children, with consistent effects seen at doses of 200mg-1000mg/day. Separately, a 2017 review in Nutrients ((PMID: 29099763)) confirmed Vitamin C's role in stimulating neutrophil chemotaxis, enhancing lymphocyte proliferation, and protecting immune cells from oxidative self-damage. At 80mg, V-DAILY meets the EU NRV for Vitamin C and contributes meaningfully to baseline antioxidant status, particularly in smokers and individuals with low fruit and vegetable intake.
The B-Complex vitamins -— including B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin) -— function as essential coenzymes in energy metabolism, DNA synthesis, and neurotransmitter production. A well-cited randomised controlled trial by Kennedy et al. (2010, (PMID: 20848523)) involving 215 healthy adults found that high-dose B-Complex supplementation over 33 days significantly reduced personal strain (-65.4%), confusion (-43%), and total mood disturbance compared to placebo, with statistically significant improvements in vigour scores. B6 and B12 in particular are critical cofactors for homocysteine remethylation; a study by Lonn et al. in the New England Journal of Medicine (2006, (PMID: 16531614)) confirmed that B6/B9/B12 combinations reduced plasma homocysteine levels by approximately 25%, a meaningful cardiovascular risk marker.
Zinc at 10mg (91% of the EU NRV) has a robust evidence base across immune, skin, and metabolic health outcomes. A randomised trial by Prasad et al. (2007, (PMID: 17344507)) demonstrated that zinc supplementation (45mg/day) in elderly individuals significantly reduced inflammatory cytokines -— TNF-α, IL-1β, and IL-8 -— compared to placebo, alongside a 66% reduction in incidence of infections over two years. At the lower 10mg dose used in V-DAILY, zinc supports baseline immune competence without risk of copper displacement, which is documented primarily at doses exceeding 40mg/day. A 2011 Cochrane review by Singh and Das ((PMID: 21328251)) confirmed that zinc supplementation within 24 hours of cold onset reduced duration by approximately one day, with lozenges showing the strongest effect; daily supplementation also reduced cold incidence by 36% in trial participants.
⚙️ Mechanism of Action
Vitamin A-derived retinoic acid activates RAR/RXR nuclear receptors to regulate immune gene expression including differentiation of Th1/Th2/Treg lymphocytes and mucosal IgA secretion, while Vitamin C donates electrons to neutralise reactive oxygen species and regenerate oxidised glutathione, simultaneously enhancing neutrophil and lymphocyte function. B vitamins act as obligate coenzymes -— riboflavin (FAD/FMN), niacin (NAD+/NADH), and pantothenic acid (CoA) -— driving mitochondrial ATP synthesis via the citric acid cycle and electron transport chain, while B6, B9, and B12 collectively sustain one-carbon metabolism for DNA methylation and homocysteine clearance. Zinc serves as a catalytic and structural cofactor in over 300 enzymes including superoxide dismutase and thymidine kinase, and functions as a signal transduction modulator that regulates thymulin activity -— a zinc-dependent thymic hormone critical for T-cell maturation and peripheral immune competence.
PubMed Citations
- Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age · PMID 21328304
- Vitamin C for preventing and treating the common cold · PMID 23440782
- Effects of B-vitamin complex supplementation on mood and wellbeing in healthy adults · PMID 20848523
- Homocysteine lowering with folic acid and B vitamins in vascular disease · PMID 16531614
- Zinc supplementation decreases incidence of infections in the elderly · PMID 17344507
- Zinc for the common cold · PMID 21328251
Frequently Asked Questions
What is V-DAILY used for?
V-DAILY is designed as a daily micronutrient foundation targeting immune support, energy metabolism, antioxidant defence, and skin and mucosal integrity. The Cochrane review by Hemilä and Chalker (2013, [PMID 23440782](https://pubmed.ncbi.nlm.nih.gov/23440782/)) confirmed Vitamin C reduces cold duration by 8–14%, while Prasad et al. (2007, [PMID 17344507](https://pubmed.ncbi.nlm.nih.gov/17344507/)) showed zinc reduces infection incidence by up to 66% in deficient elderly adults. It is most beneficial for individuals with dietary gaps, high physiological stress, frequent illness, or increased micronutrient requirements.
How long does it take to see results from V-DAILY?
Measurable immune benefits from zinc supplementation appear within 24 hours for acute cold duration (Singh & Das, 2011, [PMID 21328251](https://pubmed.ncbi.nlm.nih.gov/21328251/)), while broader immune and energy benefits from B-Complex supplementation were statistically significant after 33 days in Kennedy et al.'s RCT ([PMID 20848523](https://pubmed.ncbi.nlm.nih.gov/20848523/)). For baseline nutrient repletion in deficient individuals, plasma Vitamin C and zinc levels typically normalise within 2–4 weeks of consistent daily supplementation.
What is the optimal dose of Zinc in V-DAILY?
The 10mg dose in V-DAILY aligns with the EU Nutrient Reference Value (91% NRV) and supports immune maintenance without the risks associated with high-dose supplementation. Clinical trials using 45mg/day (Prasad et al., 2007) showed anti-inflammatory effects, but the Institute of Medicine sets the tolerable upper intake level at 40mg/day for adults; 10mg is therefore an effective, safe maintenance dose that avoids copper depletion seen at higher chronic intakes.
Are there any side effects or safety concerns?
At the doses provided in V-DAILY, all four nutrients are well within established safe intake ranges. Vitamin A at 800mcg is far below the teratogenic threshold of 3000mcg/day set by the European Food Safety Authority. Vitamin C at 80mg is well below the 2000mg/day tolerable upper limit associated with gastrointestinal distress. Zinc at 10mg is below the 25mg/day level associated with nausea in sensitive individuals. B vitamins at NRV levels have no documented adverse effects; only B6 at very high doses (>200mg/day chronically) is associated with peripheral neuropathy, which is irrelevant at standard B-Complex doses.
Can V-DAILY be combined with other supplements?
V-DAILY is compatible with most supplement regimens. Vitamin C enhances non-haem iron absorption by up to 67% (Cook & Monsen, 1977, [PMID 835796](https://pubmed.ncbi.nlm.nih.gov/835796/)), so combining with iron supplements or iron-rich meals is beneficial. However, high-dose zinc (>40mg/day) competes with copper absorption via metallothionein induction — not a concern at V-DAILY's 10mg dose. Avoid simultaneous intake of Vitamin A doses above 3000mcg/day from all combined sources during pregnancy due to teratogenic risk.
Who should take V-DAILY?
V-DAILY is most beneficial for adults with poor dietary diversity, frequent upper respiratory infections, elevated physiological stress (athletes, shift workers), older adults with age-related micronutrient absorption decline, smokers (who have 40% lower plasma Vitamin C than non-smokers), vegetarians/vegans at risk of B12 insufficiency, and pregnant or lactating women with increased folate and B12 demands. The elderly population showed the most dramatic infection-reduction benefits in Prasad's zinc trial ([PMID 17344507](https://pubmed.ncbi.nlm.nih.gov/17344507/)), with a 66% reduction in infection incidence over 24 months.
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